Welcome to the webpage of the King Laboratory in the Dept. of Microbiology and Immunology and Microbiome and Disease Tolerance Centre at McGill University!
The focus of our research is to understand how immune cells communicate with their local environment to promote protective immune responses relevant to human disease. We are particularly interested in immunity at barrier sites such as the gut, skin and lung as these tissues face the complex task of maintaining homeostasis while directly interacting with the outside world.
Ongoing studies including:
1. The molecular mechanisms of CD4+ T cell differentiation following intestinal helminth infection.
2. Intestinal epithelial cell-mediated control of Type 2 immune responses following helminth and bacterial infection.
3. Regulation of skin-resident IL-17-producing T cells in the context of psoriatic-like inflammation.
Check out this link to find out why parasites may be critical for human evolution!
This link describes how helminths can affect human fertility.
The movie above shows the cecum of a mouse infected with intestinal helminth Trichuris muris, a mouse model for human whipworm (Trichuris trichiura) infection. In this case, the cecum has been turned inside out to show how the parasite sticks its head into the intestinal epithelial layer and wiggles its tail in the gut lumen.